Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (1): 120-124.

• Mini Reviews • Previous Articles     Next Articles

Effect of NLRP3 inflammasome on cerebral ischemia-reperfusion

GUO Yan-qin, YIN Bo-kai, ZHANG Juan, HE Zhi*   

  1. Medical College of Three Gorges University,Yichang 443002,China
  • Received:2019-12-05 Revised:2020-03-26 Online:2021-01-05 Published:2020-12-30
  • Contact: *

Abstract: NLRP3 inflammasome is a polyprotein complex with complicated structure and unknown regulatory mechanism. Excessive activation of NLRP3 inflammasome is believed to be related to pathophysiological processes with multiple systemic diseases. Cerebral ischemia is the cerebrovascular disease with the highest incidence. Due to the limited application of thrombolytic therapy, it is particularly important to develop neuroprotective drugs after cerebral ischemia. Identification effective drug targets may provide new approaches in the treatment of cerebral ischemia-reperfusion injury(CIRI).

Key words: cerebral ischemia-reperfusion, NLRP3 inflammasome, activation, negative regulation

CLC Number: