Basic & Clinical Medicine ›› 2020, Vol. 40 ›› Issue (5): 701-706.

• Mini Reviews • Previous Articles     Next Articles

Progress of angiotensin converting enzyme 2 in cardiovascular diseases

JIAO Xiao-lu, QIN Yan-wen*   

  1. the Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China
  • Received:2020-03-15 Revised:2020-03-17 Online:2020-05-05 Published:2020-04-30
  • Contact: *qinyanwen@126.com

Abstract: Angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV and SARS-CoV-2(severe acute respiratory syndrom coronavirus 2) viruses, and it is also one of the main family members of renin-angiotensin-aldosterone system. ACE2 has a protective effect on cardiovascular diseases and inhibits the development of cardiovascular diseases. SARS-CoV-2 reduces the expression of ACE2 of host, which may be one of the reasons for cardiovascular complications in the later stage of coronavirus disease 2019(COVID-19). Thus, the role and mechanism of ACE2 in the development of cardiovascular diseases were summarized in this article in order to provide potential stratigy development for the treatment of COVID-19.

Key words: angiotensin-converting enzyme 2, cardiovascular diseases, renin-angiotensin-aldosterone system

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