[1]Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68: 394-424. [2]High KA, Roncarolo MG. Gene therapy[J]. N Engl J Med, 2019, 381: 455-464. [3]Lentacker I, De Cock I, Deckers R, et al. Understanding ultrasound induced sonoporation: definitions and underlying mechanisms[J]. Adv Drug Deliv Rev, 2014, 72: 49-64. [4]Helfield B. A review of phospholipid encapsulated ultrasound contrast agent microbubble physics[J]. Ultrasound Med Biol, 2019, 45: 282-300. [5]Yang J, Zhang XJ, Cai HJ, et al. Ultrasound-targeted microbubble destruction improved the antiangiogenic effect of Endostar in triple-negative breast carcinoma xenografts[J]. J Cancer Res Clin Oncol, 2019, 145:1191-1200. [6]张东旸, 杨雷, 田海, 等. 阳离子微泡提高超声波靶向击碎微泡技术体内基因靶向转染效率及治疗效果的实验研究[J]. 中国修复重建外科杂志, 2018, 32: 228-236. [7]Anderson CR, Hu X, Zhang H, et al. Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent[J]. Invest Radiol, 2011, 46: 215-224. [8]Jing H, Cheng W, Li S, et al. Novel cell-penetrating peptide-loaded nanobubbles synergized with ultrasound irradiation enhance EGFR siRNA delivery for triple negative Breast cancer therapy[J]. Colloids Surf B Biointerfaces, 2016, 146: 387-395. [9]Wan Y, Dai W, Nevagi RJ, et al. Multifunctional peptide-lipid nanocomplexes for efficient targeted delivery of DNA and siRNA into breast cancer cells[J]. Acta Biomater, 2017, 59: 257-268. [10]Sun S, Xu Y, Fu P, et al. Ultrasound-targeted photody-namic and gene dual therapy for effectively inhibiting triple negative breast cancer by cationic porphyrin lipid microbub-bles loaded with HIF1alpha-siRNA[J]. Nanoscale, 2018, 10: 19945-19956. [11]Zhao R, Liang X, Zhao B, et al. Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer[J]. Biomaterials, 2018, 173: 58-70. [12]Khalighfard S, Alizadeh AM, Irani S, et al. Plasma miR-21, miR-155, miR-10b, and Let-7a as the potential biomarkers for the monitoring of breast cancer patients[J]. Sci Rep, 2018, 8.doi:10.1038/s41598-018-36321-3. [13]Ji Y, Han Z, Shao L, et al. Evaluation of in vivo antitumor effects of low-frequency ultrasound-mediated miRNA-133a microbubble delivery in breast cancer[J]. Cancer Med, 2016, 5: 2534-2543. [14]Assali A, Akhavan O, Adeli M, et al. Multifunctional core-shell nanoplatforms (gold@graphene oxide) with mediated NIR thermal therapy to promote miRNA delivery[J]. Nanomedicine, 2018, 14: 1891-1903. [15]Kaban K, Salva E, Akbuga J. The effects of chitosan/miR-200c nanoplexes on different stages of cancers in breast cancer cell lines[J]. Eur J Pharm Sci, 2016, 95: 103-110. [16]Loh HY, Norman BP, Lai KS, et al. The regulatory role of microRNAs in breast cancer[J]. Int J Mol Sci, 2019, 20.doi:10.3390/ijms20194940. [17]Li XH, Zhou P, Wang LH, et al. The targeted gene (KDRP-CD/TK) therapy of breast cancer mediated by SonoVue and ultrasound irradiation in vitro[J]. Ultrasonics, 2012, 52: 186-191. [18]Hao Y, Guo L, Abudula A, et al. Proliferation inhibition and apoptosis enhancement of human cervical cancer cells by ultrasound-targeted microbubble destruction delivered double suicide genes[J]. Int J Clin Exp Med, 2014, 7: 5330-5335. [19]Wang L, Lu H, Gao Q, et al. A multifunctional therano-stic contrast agent for ultrasound/near infrared fluorescence imaging-based tumor diagnosis and ultrasound-triggered combined photothermal and gene therapy[J]. Acta Biomater, 2019, 99: 373-386. [20]Zhang J, Wang S, Deng Z, et al. Ultrasound-triggered drug delivery for breast tumor therapy through iRGD-targeted paclitaxel-loaded liposome-microbubble complexes[J]. J Biomed Nanotechnol, 2018, 14: 1384-1395. [21]Dimcevski G, Kotopoulis S, Bjanes T, et al. A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer[J]. J Control Release, 2016, 243: 172-181. [22]Yang D, Tan KB, Gao YH, et al. Effects of diagnostic ultrasound-targeted microbubble destruction on permeability of normal liver in rats[J]. Ultrasonics, 2012, 52: 1065-1071. [23]Vancraeynest D, Havaux X, Pouleur AC, et al. Myocar-dial delivery of colloid nanoparticles using ultrasound-targeted microbubble destruction[J]. Eur Heart J, 2006, 27: 237-245. [24]Yoon YI, Yoon TJ, Lee HJ. Optimization of ultrasound parameters for microbubble-nanoliposome complex-media-ted delivery[J]. Ultrasonography, 2015, 34: 297-303. [25]Qu N, Shi D, Shang M, et al. Breast cancer cell line phenotype affects sonoporation efficiency under optimal ultrasound microbubble conditions[J]. Med Sci Monit, 2018, 24: 9054-9062. |