Progress in research on pyroptosis and cardiovascular diseases

Abstract

Abstract: Pyroptosis is a kind of programmed cell death mediated by the gasdermin protein, including the classical pathway that depends on caspase-1 and the non-classical pathway that depends on caspase-4, -5, and 11, accompanied by the release of a large number of inflammatory factors. Atherosclerosis, myocardial ischemia, heart failure and other cardiovascular diseases are closely related to inflammatory response. Pyroptosis, as a highly pro-inflammatory cell death, is also widely involved in the occurrence and development of the cardiovascular diseases, and plays an important role in these diseases.

Key words: pyroptosis, inflammasomes, cardiovascular diseases

CLC Number:

R331.3

ZHU Kun, DAI Ri-lei, ZHU Wen-ting, LI Zhen-yan, CAO Chun-mei. Progress in research on pyroptosis and cardiovascular diseases[J]. Basic & Clinical Medicine, 2020, 40(12): 1711-1715.

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