Basic & Clinical Medicine ›› 2020, Vol. 40 ›› Issue (12): 1661-1665.

• Original Articles • Previous Articles     Next Articles

Antibiotic resistance of Helicobacter pylori:a multicenter prospective analysis

YE Shan-shan1, LI Jun-da2, ZHOU Ying-sheng3, LIU Lu1, WU Jian-wei1, LYU Zhi-wu1, LIU Jin-tao1*   

  1. 1. Department of Gastroenterology, People's Hospital of Baoan Shenzhen, Guangdong Medical University,Shenzhen 518101;
    2. Department of Gastroenterology, People's Hospital of Longhua Shenzhen, Shenzhen 518109;
    3. Department of Gastroenterology, Shenzhen Hospital, University of Chinese Academy of Sciences, Shenzhen 518107,China
  • Received:2020-02-03 Revised:2020-04-25 Online:2020-12-05 Published:2020-11-30
  • Contact: * bill-liu118@163.com

Abstract: Objective To investigate the infection of Helicobacter pylori (Hp) and its resistance to six kinds of antibiotics in Shenzhen. Methods Urease test and Hp cultivation were performed in 5 080 patients with gastrointestinal discomfort in three hospitals in Shenzhen, and antibiotic sensitivity test of agar dilution was performed. Results Among the 5 080 patients, a total of 3 203 patients were Hp positive, with a positive rate of 63.05%. The resistance rate of 3 203 Hp strains to antibiotics was metronidazole (MNZ)(99.6%),amoxicillin(AMX)(30.5%),clarithromycin(CAM)(10.6%), doxycycline (DOX) (0.3%), furazolidone(FR) (0.2%), and levofloxacin(LVX) (0.1%). The rates of total sensitivity to Hp was 0.18%, single drug resistance, double and multiple drug resistance were 62.06%, 33.94% and 3.81%, respectively. MNZ and AMX had the highest double drug resistance (26.69%), while MNZ, CAM and AMX had the highest triple drug resistance (3.68%). The age ≤40 years seems to be a factor for single antibiotic resistance, while the age >40 years is a risk factor for double antibiotic resistance of Hp strain. Gender is an influence factor of Hp strain on CAM and single and double antibiotic resistance. Conclusions Hp has a high infection rate and high resistance to MNZ, followed by AMX and CAM.

Key words: Helicobacter pylori, antibiotics, resistance

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