Abstract: Objective Investigate the effects of copper on lipid metabolism in diet by establishing different doses of copper intake models. Methods The body weight index of mice with different copper content of food was continuously monitored within two months, and the proportion of liver and abdominal adipose tissue, serum lipids,fat metabolism related enzyme activity and mRNA levels as well as glucose tolerance were measured at the end of the experimental intervention. Results High doses of copper can affect the growth of mice's body weight(P<0.001), promote the hydrolysis of body triglycerides(P<0.01), reduce the content of triglycerides in serum(P<0.01), and cause impaired glucose tolerance(P<0.05). Conclusion Copper overload can inhibit the synthesis of triglyceride in the liver of mice, promote lipid degradation, fatty acid oxidation, and affect lipid metabolism.

Key words: Key words: Copper overload, Copper deficiency, Lipid metabolism