Abstract: Pyroptosis is a programmed inflammatory cell necrosis medicated by gasdermin protein, including caspase-1-mediated canonical pathway and caspase-4/5/11-mediated noncanonical pathway. Inflammasome activation plays an important role in this process. Pyroptosis plays an important role in the development and progression of renal diseases, atherosclerosis, nervous system diseases, infectious diseases, etc. The study on the mechanism of pyroptosis and related diseases provides new ideas for the prevention and treatment of clinical diseases.

Key words: pyroptosis, inflammasome, caspase-1/4/5/11, GSDMD