Abstract: Notch signaling pathway is a highly conserved signaling pathway that directly mediates the signal cascade between cells and cells. It has a regulatory effect on differentiation, proliferation, and apoptosis of a variety of cells. It has been found that activation or inactivation of Notch signaling pathway plays a very important role in the intestinal mucosal barrier. Provides new insights and ideas for the treatment of intestinal mucosal barrier damage caused by various diseases.

Key words: Notch signaling pathway, intestinal mucosa, intestinal mucosal barrier, intestinal epithelial cells