Abstract: Objective To compare the between effects oxaliplatin combined with fluorouracil and paclitaxel combined with fluorouracil in the treatment of advanced gastric cancer(AGC)．Methods We selected 89 cases of patients with advanced gastric cancer and divided then into 2 groups, with least 3 months’ chemotherapy. The group A was treated with oxaliplatin 130 mg /m2 combined with fluorouracil 40mg /m2. The Group B was treated with paclitaxel 135-175 mg /m2 combined with fluorouracil 40mg /m2. Results The ORR of group A was 38.78% higher than Group B, 37.50%, after two cycle of chemotherapy. After three months’ chemotherapy, no differencs was found between group A (ORR 51.02%, DCR 71.43%) and group B (ORR 47.50%, DCR 75.00%). Adverse reactions of group A were less than group B (P<0.05). The median PFS of group A was 4.3 months, and the median PFS of group B was 3.9 months. The difference between the groups by Log-rank test was statistically significant. Conclusions After 3-month treatment no difference is between oxaliplatin combined with fluorouracil and paclitaxel combined with fluorouracil, However the oxaliplatin combined with fluorouracil is higher rate of short-term remission, and less adverse reactions.

Key words: Oxaliplatin, Fluorouracil, Paclitaxel, Advanced Gastric Cancer