Basic & Clinical Medicine ›› 2018, Vol. 38 ›› Issue (5): 708-712.

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Effect of ACE/AngII/AT1 axis and ACE2/Ang(1-7)/Mas axis on glucose and lipid metabolism in adipose tissue

  

  • Received:2018-01-11 Revised:2018-03-21 Online:2018-05-05 Published:2018-04-28
  • Contact: Ming-Xia YUAN E-mail:yuanmx@vip.126.com

Abstract: The renin angiotensin system includes two counterbalance axes: the ACE/AngII/AT1 axis and the ACE2/Ang(1-7)/Mas axis. The RAS can regulate glucose and lipid metabolism in adipose tissue. Most of evidences demonstrated that the ACE/AngII/AT1 axis can induce glucose metabolism disorders in adipose tissue,on the contrary, the ACE2/Ang(1-7)/Mas axis improves glucose metabolism. The RAS , which is over activated in obese patient, has been considered to be a potential link between obesity, dyslipidemia and insulin resistance. The effect of ACE/AngII/AT1 axis and ACE2/Ang(1-7)/Mas axis on lipid and glucose metabolism in adipose tissue should be futher investigated, and we may find a new target for improving glucose and lipid metabolism.

Key words: renin-angiotension system (RAS), ACE/AngII/AT1 axis, ACE2/Ang(1-7)/Mas axis, adipose tissue, glucose and lipid metabolism

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