Basic & Clinical Medicine ›› 2018, Vol. 38 ›› Issue (12): 1766-1770.

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Pyroptosis and tissue fibrosis

  

  • Received:2018-08-06 Revised:2018-10-24 Online:2018-12-05 Published:2018-11-23

Abstract: Pyroptosis is a new type of programmed cell death that is specific to caspace-1. Associated stimuli activate inflammatory corpuscles and initiate pyroptosis, leading to cell death and the release of inflammatory factor IL-1β and IL-18. Pyroptosis mediates the axial pathological changes of "pyroptosis-inflammatory response-fibrosis" in many kinds of fibrosis diseases, expands inflammatory cascade reaction, and exacerbates the course of tissue fibrosis. Therefore, the initiation of cell pyroptosis has gradually become a new direction of drug target.

Key words: Pyroptosis, Inflammasome, GSDMD, Tissue fibrosis

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