Basic & Clinical Medicine ›› 2018, Vol. 38 ›› Issue (12): 1766-1770.
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Abstract: Pyroptosis is a new type of programmed cell death that is specific to caspace-1. Associated stimuli activate inflammatory corpuscles and initiate pyroptosis, leading to cell death and the release of inflammatory factor IL-1β and IL-18. Pyroptosis mediates the axial pathological changes of "pyroptosis-inflammatory response-fibrosis" in many kinds of fibrosis diseases, expands inflammatory cascade reaction, and exacerbates the course of tissue fibrosis. Therefore, the initiation of cell pyroptosis has gradually become a new direction of drug target.
Key words: Pyroptosis, Inflammasome, GSDMD, Tissue fibrosis
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2018/V38/I12/1766