Basic & Clinical Medicine ›› 2017, Vol. 37 ›› Issue (8): 1170-1174.
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Abstract: c-kit+ cells are mainly derived from bone marrow and cardiac tissue. The cells include various subpopulations. Recent studies have shown that c-kit+ cells are a kind of ideal cells of transplantation therapy for myocardial infarction. However, there is a great debate on the differentiation efficiency of c-kit+ cells towards cardiomyocytes and endothelial cells. Therefore, it is necessary to evaluate the potential of c-kit+ cell differentiation and explore the effects of different developmental stages and microenvironments on differentiation of c-kit+ cells again. These studies could be significant for increasing efficiency of c-kit+ cell transplantation in repairing the infarcted myocardium.
Key words: c-kit+ cells, cardiomyocytes, endothelial cells, ischemic disease
CLC Number:
R34
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2017/V37/I8/1170