Abstract: Objective To investigate the anti-HBs level within 15 years after vaccination in adults and newborns in Beijing and provide the suggestion for the adult hepatitis B (HB) immunization plan. Methods A serological survey was conductedin 6705 subjects aged > 1 year old by multistage randomized cluster sampling in Beijing during August 2013 to February 2014. The subjects whohad received a 3-dose recombinationHB vaccine when they were newborns or adults aged ≥15 years old and did not undergo revaccination were selected. Antibody to hepatitis B surface antigen (anti-HBs)titers and positive rates within 15 years after vaccination wereevaluated. Results A total of 129 and 493 subjects who were vaccinated in adults and newborns were enrolled in the study. Based on the self-limited rate, 30%, of HBV infection among the general population aged 15 to 59 years, anti-HBs positive rates for the subjects vaccinated in adults were estimated to be 58.6%，62.5%and 48.4%during 0 -4, 5 - 9 and 10 - 15 years after vaccination respectively. The corresponding median of anti-HBs titers were 288.8, 120.6 and 62.6mIU/mL.The anti-HBspositive rates for the subjects vaccinated in newbornsduring 0 - 4, 5 - 9 and 10 - 15 years after vaccination were 83.3%, 47.3% and 43.5%, respectively. The corresponding anti-HBs titerswere 71.8, 8.9,and 6.7mIU/mL. Conclusions The protection afforded by primary immunization with recombination vaccine in adults and newborns lasts at least 15 years.

Key words: Hepatitis b vaccine, Adult, Infancy, Antibody, Positive rate