Abstract: Objective To assess the association of the concentration of SO2 and NO2 with diabetes in Nanjing. Methods We collected air pollution, meteorological data and diabetes-related deaths in Nanjing from 1 January 2008 to 31 December 2011 and conducted a time-stratified, bi-directional case-crossover design to examine theassociation. Subgroup analyses were performed after stratification by age, gender and season. Results The ORs of the diabetes-related mortality associated with each10μg/m3 elevation of SO2 and NO2were approximately 1.031 (95% CI: 1.005, 1.058), 1.042 (95% CI: 1.012, 1.074). SO2 and NO2 were significantly associated with diabetes-associated deaths in the old people and in winter. Conclusions This studyprovides evidences that NO2 and SO?2 in Nanjing are significantly associated with diabetes- related deaths.

Key words: NO2, SO2, diabetes, mortality, case-crossover design