Abstract: Objective To investigate the expression of the miR-96 and metastasis suppressor 1(MTSS1) in prostate cancer and their clinical significances. Methods Compaired with adjacent tissue, hybridization in situ and immunohistochemistry were used to detect the miR-96 and MTSS1 expression in collected prostate cancer tissue specimens from 89 cases patient. Results The positive expression rate of the miR-96 and MTSS1 were 87.64%, 16.85% in respectivly prostate cancer (P<0.01). The up-regulation of miR-96 expression was associated with Gleason score and advanced clinical stage(P<0.05), and the expression of miR-96 was higher with bone metastasis than without bone metastasis in prostate cancer(P<0.05). But the down-regulation of MTSS1 expression was associated with Gleason score and advanced clinical stage(P<0.05), the expression of MTSS1 was lower with bone metastasis than without bone metastasis in prostate cancer(P<0.01). The expression of miR-96 had a close negative correlation to that of MTSS1 in prostate cancer (P<0.01). Conclusions miR-96 and MTSS1 may be important biological markers of bone metastasis in prostate cancer.

Key words: miR-96, MTSS1, prostate cancer, bone metastasis