Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (4): 542-546.
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Abstract: Notch signaling pathway is a highly conservative signaling pathway, which plays a key role in regulation of cell differentiation, proliferation and apoptosis, as well as a series of physiological and pathological processes. Notch signaling was frequently found to be mutation of abnormal expression and activation in hepatocellular carcinoma(HCC), which promoted the development of HCC through a variety of mechanisms and closely related to the invasion, metastasis and prognosis of HCC. Thus, Notch signaling may become a new target for treatment of HCC, providing new directions and opportunities for HCC.
Key words: Notch, signaling, hepatocellular carcinoma
CLC Number:
R730.5
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2016/V36/I4/542