Abstract: Resveratrol is a kind of natural plant extract with low toxicity. In recent years, studies have shown that resveratrol can enhance the sensitivity of resistant cells to chemotherapy drugs and significantly reverse the Multi-drug resistance(MDR) of tumor by mechanisms such as ATP-binding cassette transporter family, signaling pathways, SIRT1, induction of apoptosis and so on , which will provide a new thought to solve the problem of MDR. Above all, resveratrol is respected to become a novel MDR reversal agent.

Key words: resveratrol, tumor, multi-drug resistance, reversal agent