Progress in epigenetic regulation of endotoxin tolerance

Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (12): 1733-1737.

Progress in epigenetic regulation of endotoxin tolerance

Received:2016-02-25 Revised:2016-04-29 Online:2016-12-05 Published:2016-11-29

Abstract

Abstract: Endotoxin tolerance is a protective mechanism of excessive inflammatory response. TLR4 signaling pathway plays critical roles in endotoxin tolerance. Epigenetics is a phenomenon that alters gene expression pattern without DNA sequence;it could modulates the process of endotoxin tolerance through microRNA, long non-coding RNA regulation and histone modification.

Key words: endotoxin tolerance, epigenetic regulation, microRNA, IncRNA, histone modification

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Progress in epigenetic regulation of endotoxin tolerance

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