Abstract: High airway mucus secretion is mainly characterized by the changes of airway mucus in the physicochemical property, including the changes of mucus components which are mainly changed with MUC5AC and mucous secretory cells which are mainly changed from mucus cells to goblet cells. The harmful inhalation substance mainly in cigarette smoke and bacterial infection are the main irritants to induce the high airway mucus secretion. Besides, heat shock protein, signal transduction pathway and the increase of MUC5AC expression are the major mechanisms of high airway mucus secretion .

Key words: Key words: mucus hyper-secretion, chronic airway inflammation, mucin