Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (10): 1437-1440.

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Research progress of SWI/SNF chromatin remodeling in malignancies

  

  • Received:2015-10-22 Revised:2015-12-30 Online:2016-10-05 Published:2016-09-27

Abstract: The mutations of SWI/SNF subunits genes, with about 20% high in human cancers, promote oncogenesis by inactivating the function of encoding proteins and further perturbing the whole function of SWI/SNF complexes. The main yet known mechanisms by which SWI/SNF suppress tumor development include its epigenetic antagonism with Polycomb complexes, as well as synergetic interaction with other oncogene signaling such as c-Myc and PIK3CA.

Key words: Key words: SWI/SNF, chromatin remodeling, ARID1A

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