Abstract: The mutations of SWI/SNF subunits genes, with about 20% high in human cancers, promote oncogenesis by inactivating the function of encoding proteins and further perturbing the whole function of SWI/SNF complexes. The main yet known mechanisms by which SWI/SNF suppress tumor development include its epigenetic antagonism with Polycomb complexes, as well as synergetic interaction with other oncogene signaling such as c-Myc and PIK3CA.

Key words: Key words: SWI/SNF, chromatin remodeling, ARID1A