Abstract: Caveolae is the key molecular that regulates the permeability of vascular endothelial cells through Cav-1 expression and phosphorylation, Src kinase activation and paracellular permeability. Caveolae and Cav-1 participate in the process of LDL transport across the cell, regulate the blood-brain barrier, interpose the tumor pathological angiogenesis and the pulmonary endothelial barrier,and provide new therapeutic targets for atherosclerosis, stroke and other cardiovascular and cerebrovascular diseases and certain cancers.

Key words: Caveolae, transcellular transport, endothelial permeability, therapeutic target