The role of AXL in tumor metastasis and drug resistance and strategy in anti-tumor therapies

Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (1): 112-115.

The role of AXL in tumor metastasis and drug resistance and strategy in anti-tumor therapies

Received:2015-03-23 Revised:2015-07-20 Online:2016-01-05 Published:2015-12-29

Abstract

Abstract: The receptor tyrosine kinase (RTK) AXL is over expressed in multiple tumor cells and mediates the metastasis and drug resistance of tumor cells through a variety of signaling pathways, especially form positive feedback loops with EMT, therefore has become a new tumor therapeutic target. By inhibiting the expression of AXL can effectively reverse EMT and tumor metastasis and drug-resistance.

Key words: Key words: AXL, cancer cell, metastasis, invasion, drug resistance

CLC Number:

[1]	. Expression of HMG-CoA2-ligase in nasopharyngeal carcinoma and its influence on the cell proliferation and invasion of nasopharyngeal carcinoma cells [J]. Basic & Clinical Medicine, 2019, 39(9): 1294-1299.
[2]	. Interference with ARF6 inhibits proliferation, migration and invasion of human prostate cancer cell line DU145 [J]. Basic & Clinical Medicine, 2019, 39(9): 1310-1315.
[3]	. Stemness of the sphere formed human osteosarcoma cell line MG-63 [J]. Basic & Clinical Medicine, 2019, 39(2): 230-234.
[4]	. Up-regulation expression of miR-195-5p inhibits the migration and invasion of lung cancer cell line A549 [J]. , 2019, 39(12): 1694-1698.
[5]	. miR-195 inhibits cell proliferation, migration and invasion of tongue squamous cell carcinoma cell line CAL27 [J]. , 2019, 39(12): 1689-1693.
[6]	. Icariin inhibits proliferation, migration and invasion of MGC803 cell line by down-regulating metastasis-associated protein 2 [J]. , 2019, 39(11): 1587-1591.
[7]	. Sevoflurane inhibits proliferation, migration and invasion of human breast cancer cell line MCF-7 [J]. , 2019, 39(11): 1597-1602.
[8]	. Enhanced IL-8 expression in epithelial mesenchymal transformation of gastric cancer tissue [J]. Basic & Clinical Medicine, 2019, 39(10): 1444-1448.
[9]	. Effect of DKK3 on migration and invasion of colorectal cancer HCT116 cell line [J]. Basic & Clinical Medicine, 2019, 39(10): 1437-1443.
[10]	. Tumor markers and angiogenic factors are related to clinical staging and metastasis in colorectal cancer patients [J]. Basic & Clinical Medicine, 2019, 39(1): 59-62.
[11]	. miR-34a inhibits the invasion and metastasis of glioma cells through MMP2 [J]. Basic & Clinical Medicine, 2018, 38(8): 1115-1120.
[12]	. Significance of SOX2 and CTBP1 interactions in metastasis of non-small cell lung cancer [J]. Basic & Clinical Medicine, 2018, 38(8): 1105-1110.
[13]	. Twist promotes cell migration and invasion in human breast cancer cell line Hs578T [J]. Basic & Clinical Medicine, 2018, 38(6): 771-775.
[14]	. miR-210 plays a role in the transformation from mesenchymal stem cells (MSCs) into cancer-associated fibroblasts (CAFs) [J]. Basic & Clinical Medicine, 2018, 38(6): 780-786.
[15]	. TRIM11 promotes proliferation and invasion of breast cancer cell line MCF7 by targeting miR-24-3p [J]. Basic & Clinical Medicine, 2018, 38(4): 451-457.

The role of AXL in tumor metastasis and drug resistance and strategy in anti-tumor therapies

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments