Abstract: SWI/SNF is an ATP-dependent chromatin remodeling complexes. ARID1A gene is an important subunit of SWI/SNF complexes and its dysfunction can cause abnormal chromatin remodeling resulting in tumorigenesis. ARID1A occurs frequently low expression or deletion mutation in a variety of malignant tumors, such as ovarian cancer, liver cancer, breast cancer, stomach cancer, lung cancer and so on which indicates ARID1A is an important tumor suppressor gene.

Key words: ARID1A, chromatin remodeling, tumor suppressor gene, malignant tumor