Basic & Clinical Medicine ›› 2015, Vol. 35 ›› Issue (9): 1267-1270.

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Advances in research on ARID1A in Malignancies

  

  • Received:2015-02-11 Revised:2015-04-19 Online:2015-09-05 Published:2015-09-07
  • Contact: Xun LI E-mail:lxdr21@126.com

Abstract: SWI/SNF is an ATP-dependent chromatin remodeling complexes. ARID1A gene is an important subunit of SWI/SNF complexes and its dysfunction can cause abnormal chromatin remodeling resulting in tumorigenesis. ARID1A occurs frequently low expression or deletion mutation in a variety of malignant tumors, such as ovarian cancer, liver cancer, breast cancer, stomach cancer, lung cancer and so on which indicates ARID1A is an important tumor suppressor gene.

Key words: ARID1A, chromatin remodeling, tumor suppressor gene, malignant tumor

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