Basic & Clinical Medicine ›› 2015, Vol. 35 ›› Issue (7): 980-984.
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Abstract: In recent years, it has been attracting more and more attention to the relationship between obesity and autophagy. Autophagy in different tissue cell plays a different role under the obese state. Adipose-specific deletion of autophagy-related gene 7 and gene 5 have reduced the accumulation of lipid droplets and improved insulin resistance;Increased autophagy in hepatocytes may improve the metabolism;Autophagy defects in pancreatic β-cells may damage cells function;The appropriate level of autophagy is very important to maintain the function of skeletal muscle homeostasis.
Key words: Obesity, Adipocyte, Hepatocyte, Autophagy
CLC Number:
R392
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