Abstract: Objective To evaluate the efficacy of postoperative analgesia in patients after total knee replacement. Methods 430 patients who had total knee replacement between January 2011 and June 2012 at Peking Union Medical College Hospital were enrolled. Results Continous femoral nerve block had better pain control for patients after total knee replacement. Morphine and sufentanil had similar analgesic effect for intravenous patient control analgesia. Side effects, including nausea and vomiting were higher in morphine group. Conclusion Postoperative pain after total knee replacement is usually severe and multi-model analgesia is necessary for this group of patients.

Key words: acute postoperative pain, intravenous patient control analgesia, continous femoral nerve block, visual analogue scale, total knee replacement