Basic & Clinical Medicine ›› 2015, Vol. 35 ›› Issue (5): 661-664.

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Interaction of miR-26b and lncRNA SNHG5 in gastric cancer


  • Received:2014-12-24 Revised:2015-03-12 Online:2015-05-05 Published:2015-04-28

Abstract: Objective To explore the interaction and mechanism between miR-26b and lncRNA SNHG5. Methods Quantitative real-time PCR analyzed the differential expression of SNHG5 in normal gastric epithelial cell GES-1 compared with it in gastric cancer cell. Transient transfected MGC-803 cells with SNHG5 overexpressed plasmid and detect the expression level of miR-26b and pri-miR-26b by Taq Man PCR analysis. Meanwhile, transient transfected MGC-803 cells with miR-26b mimics to detect the expression change of SNHG5. Results Expression level of SNHG5 was significantly higher in gastric cancer cells than in normal gastric epithelial cell GES-1 (P<0.05). SNHG5 inhibited the expression of miR-26b and pri-miR-26b(P<0.01), but miR-26b could not influence the expression of SNHG5. Conclusion SNHG5 inhibited the expression of miR-26b, but the mechanism need to be further clarified.

Key words: Gastric cancer, SNHG5, miR-26b

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