Abstract: MicroRNAs (MiRNAs) is one kind of highly conservative endogenous non-coding single-stranded RNAs with small molecule, it is able to regulate gene expression at the translation level by non-specific identification of target genes’ mRNA, and it can regulate various biological functions of cells. Up to now a variety of microRNAs have been found, in which MiR-126 mainly exists in vascular endothelial cells and platelets, and is closely related to the generation, development and repairing of blood vessels. Therefore, MiR-126 will become a very good breach to study coronary heart disease and other vascular diseases.

Key words: miR-126, blood vessel, VEGF, VCAM-1