Abstract: mGlu5 ( Metabotropic glutamate receptor 5 ) does not only exist in nervous system, but also in many peripheric organs and tissues. The vital role that mGlu5 plays in both nervous and non-nervous system diseases, which will be beneficial for further studying the pathogenesis of diseases. Moreover, it can provide us with new ideas and methods for precaution and cure of illness with mGluRs.

Key words: Metabotropic glutamate receptor 5, nervous system diseases, non- nervous system diseases