Abstract: Eye is one of the most suitable organs for gene therapy. With the understanding of TGF-β signaling pathway and progressing in the technology of miRNA and RNAi，Gene therapy is more promising in curing ocular fibrotic disorders. Although the gene therapy research in kinds of eye fibrotic diseases is developing rapidly, many problems need to be solved.

Key words: Gene therapy, ocular fibrotic disorders, Transforming growth factor beta, MicroRNA, RNA Interference