Abstract: Objective To evaluate whether ondansetron added to intravenous patient analgesia solution with morphine will reduce postoperative nausea and vomiting. Methods Data of surgical female inpatients in PUMCH from January 1st to June 30th, 2012 who performed general anesthesia and intravenous analgesia solution with morphine postoperatively were analyzed. Results Data from 578 cases were analyzed. Cases of no adding ondansetron to intravenous analgesia solution were 55, compared to adding ondansetron group were 523 (ondansetron 0.2mg~0.5mg/h for 48 hours). The maximum VAS score of postoperative pain at rest, the maximum VAS score of postoperative pain during movement and postoperative sedation scores were no significantly different. The maximum score of postoperative nausea, and cumulated frequency of postoperative vomiting during first 48 hours were no significantly different. Conclusion Ondansetron added to intravenous patient-control analgesia solution with morphine could not reduce postoperative nausea and vomiting in female patients.

Key words: PONV (post operative nausea and vomiting), ondensetron, intravenous patient control analgesia, VAS(visual analogue scale)score