Abstract: Necroptosis is a special cell necrosis that is capable of being regulated through particular molecular mechanism. Multiple stimuli could induce necroptosis , complex I, complex II and RIP1-RIP3 necrosome are critical participants in the necroptosis. Also, necrostatin-1 is a special and potent small-molecular inhibitor of necroptosis. Necroptosis could be an important alternative for cell death in ischemia-reperfusion injury.

Key words: Necroptosis, receptor interaction protein kinase 1, receptor interaction protein kinase 3