Abstract: Limb ischemic disease has become one of the major diseases of developed countries as well as many developing countries, and stem cell transplantation is a new method for treatment in limb ischemic diseases ,it has attracted much attention. Endothelial progenitor cells (EPCs) can differentiate into endothelial cells involved in angiogenesis. Many studies have confirmed that the transplanted EPCs in the body can promote angiogenesis in ischemic tissue.

Key words: endothelial progenitor cells, angiogenesis, ischemic disease