Abstract: Glioma stem cells play a crucial role in glioma recurrence and resistance to therapies. Notch signaling pathway was involved in glioma stem cells' forming and maintaining. Moreover, Notch activation was contributed to chemotherapy and radiotherapy of resistance in glioma. Therefore, the study on Notch signaling pathway of glioma stem cells has positive significance for the development of targeted therapies.

Key words: notch signaling pathway, glioma stem cells, anti-therapy, stem cell maintenance