Progress on type II transmembrane serine protease

Basic & Clinical Medicine ›› 2013, Vol. 33 ›› Issue (7): 915-918.

Progress on type II transmembrane serine protease

Received:2012-08-06 Revised:2012-10-24 Online:2013-07-05 Published:2013-06-26

Abstract

Abstract: The type II transmembrane serine protease (TTSP) family includes a group of trypsin-like enzymes that are anchored on the cell surface via an integral transmembrane domain near the N-terminus. The activated TTSPs cleave their specific substrates to participate in a variety of physiological and pathological processes. Dysregulation of these TTSPs may lead to serious diseases such as cancer, hearing loss, anemia and cardiovascular disease.

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Progress on type II transmembrane serine protease

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