Abstract: Objecive To explore the expressions of HMGB1 and TLR2/TLR4 in the patients with rheumatoid arthritis. Methods To select 29 active RA, 20 inactive RA and 18 controls.The expression of HMGB1 in serum of these cases were detected by ELISA. The expression of TLR2 and TLR4 on CD14+ monocytes in peripheral blood were detected by FCM. Results The HMGB1 content and the expression rate and relative protein quantification of TLR2 and TLR4 on CD14+ monocytes in active RA was significantly higher than inactive group and controls; The expression of and relative protein quantification of TLR4 CD14+ monocytes in inactive group is higher than controls. The level of HMGB1 in serum in active RA was positively correlated with the relative protein quantification of TLR2 and TLR4. Conclusion The expression of HMGB1 and TLR2/TLR4 in RA may be associated with the occurrence and development of RA and synchronous in rheumatoid arthritis.

Key words: Arthritis,rheumatoid, HMGB1, TLRs