Basic & Clinical Medicine ›› 2013, Vol. 33 ›› Issue (2): 239-244.

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Diagnostic value of mitochondrial DNA content alterations in human cancers

  

  • Received:2012-03-06 Revised:2012-05-11 Online:2013-02-05 Published:2013-01-25
  • Contact: Ying FENG E-mail:fyingyy@163.com

Abstract: This review summarizes mtDNA content changes present in various types of common human malignancies and briefly describe its potential connections to the carcinogenic process. The review states the value of altered mtDNA content to be utilized as a diagnostic biomarker for identifying risk of cancer and early surveillance program.

Key words: mitochondrial DNA, cancer, biomarkers.

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