Abstract: Objectives To analysis the effect of open surgery of methylene blue calibration around the lower esophageal segment cardia lymph on postoperative 3-year disease-free survival rate and 5-year overall survival rate. Methods Patients less than 70-year-old, the cardia single tumor less than 8cm, stage Ⅰ to ⅢB were randomly divided into 2 groups. Group A: D2 radical mastectomy. Group B: injected into the methylene blue around the cardia tumor and surrounding lymph nodes, so as to guide cleaning resection. Patients were followed up for 5 years.Results A postoperative 3-year disease-free survival and overall 5-year survival rates were 59% and 37%. Group B 74% and 53% respectively.Conclusions Intraoperative lymph nodes around the tumor look straight down the calibration can be more complete excision and sentinel lymph node was stained and visually difficult to find< 2mm tiny positive lymph nodes, increased after 3-year disease-free survival and overall 5-year survival rate. The technique is simple and feasible, practical, clinical applications could be extended.

Key words: the cardia tumor, lymphatic metastasis, lymph node staining, survival rate