Abstract: Objective To describe a rare manifestation of primary hyperparathyroidism in association with papillary thyroid carcinoma and to decrease misdiagnosis and missed diagnosis.Methods We describe the clinical history, findings on physical examination, results of laboratory studies,imaging findings, and histopathologic features of three patients who were diagnosed hyperparathyroidism and papillary thyroid carcinoma in PUMCH from 1983∽2011.Results There are two women and a men,from 37 to 59 years old.They were presented to our clinic because of primary hyperparathyroidism .Serum Ca 2.78∽3.1 mmol/L,PTH 202∽241pg/mL,MIBI(+).Ultrasonography revealed solitary nodule in two people,another is no.At first, Parathyroidectomy was performed in three of them .Then ,Total thyroidectomy was performed,two of them were proposed in two step. Conclusion The concurrence of primary hyperparathyroidism and papillary thyroid carcinoma are rare. Intraoperative evaluation of the thyroid is as important as preoperative evaluation with ultrasonography in patients with thyroid and parathyroid.

Key words: primary hyperparathyroidism 1, papillary thyroid carcinoma 2, diagnosis 3, treatment 4