Basic & Clinical Medicine ›› 2013, Vol. 33 ›› Issue (1): 123-125.
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Abstract: Eukaryotic initiation factor 5A2 gene is a highly conserved gene of EIF5A family. EIF5A2, as a potential oncogene, was highly expressed in a variety of human tumors, and associated with the staging and / or poor prognosis of the tumor. EIF5A2 induces epithelial mesenchymal transition through a variety of the mechanisms, and thus promote tumor invasion and metastasis. EIF5A-MTA1/c-MYC axis may be one of the important pathways involved in regulation of tumor invasion and metastasis. The underlying molecular mechanisms need further studies.
Key words: EIF5A2, cancer, metastasis
CLC Number:
R735.2
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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2013/V33/I1/123