Research Progress of ATP-binding cassette transporter A1 Genovariation Association with Coronary Artery Disease

Abstract

Abstract: Abstract: Abnormal lipid metabolism plays an important role in the pathogenesis of coronary artery disease (CAD), ATP-binding cassette transporter A1 (ABCA1) is the rate limiting step in the reverse cholesterol transport(RLT) and high density lipoprotein(HDL) production. ABCA1 genovariation can cause abnormal lipid metabolism, promoting the development of atherosclerosis and CAD. This paper is about the study progress of ABCA1 genovariation and its effect on the pathogenesis of CAD.framework、genovariation and clinical application with CAD.

Key words: ATP-binding cassette transporter A1, high density lipoprotein, gene polymorphism, coronary artery disease

References

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