Abstract: Abstract:Objective To study correlation of the ART1 expression with VEGF and Integrin αVβ3 expression and the affection of ART1 to mieroangiogenesis in colorectal carcinoma.Methods Immunohistochemical be used to detect the expression of ART1, VEGF and Integrin αVβ3, and immunofluorescence double staining be used to detect co- expression of ART1/ VEGF and ART1/Integrin αVβ3;and the microvascular density(MVD) quantified by Chalkley analysis Results The expression of ART1，VEGF and integrin αVβ3 was significantly higher than in control group(P<0．05) ,and there is a positive correlation of ART1 with VEGF and Integrin αVβ3．The group of co-expression of ART1/ VEGF and Integrin αVβ3 show higher microvessel density(25.4±8.23，22.3±5.9) than the group of non-co-expression group(5.5±2.0和8.1±3.3，P

Key words: ART1, VEGF, integrin αVβ3, colorectal carcinoma, angiogenesis