Abstract: [Abstract] Objective: Through observation of puerarin on osteoporosis in ovariectomized rats and rats with lead poisoning Haierfu on the treatment of osteoporosis, as in Traditional Chinese treatment of osteoporosis and postmenopausal osteoporosis in rats with lead poisoning and provide experimental Basis.. Methods: 5 months old female rats 100, divided into five experimental groups (n = 20): (1) control group (Nomal); (2) to the ovariectomy group (OVX); (3) lead poisoning model group (PLD); (4) OVX + puerarin group (P + OVX); (5) lead poisoning Haierfu + group (H + PLD), the experimental group at 12 weeks observed from rat femur bone tissue biopsy, blood Measuring serum calcium, phosphorus and alkaline phosphatase, the data were statistically analyzed.. Results: OVX group and the PLD group showed a light microscope, the pathological changes of osteoporosis, calcium, phosphorus was significantly lower than Nomal group (P <0.01), while the ALP was significantly higher than Nomal group (P <0.01). P + OVX group and the H + PLD group compared with the Nomal calcium, phosphorus, and alkaline phosphatase were no significant differences (P> 0.05), 2 treatment groups had no significant pathological changes of osteoporosis. Conclusion: Puerarin on ovariectomized rats osteoporosis and Haierfu on osteoporosis in rats of lead poisoning have a good therapeutic effect; lead poisoning can cause osteoporosisAnd reduced hemoglobin

Key words: Puerarin, Haierfu, ovariectomized rats, Lead poisoning, Osteoporosis