Abstract: [Abstract] Objective: To investigate the expression of p53，ki-67, galectin-3, HBME-1, 34βE12 and CK-19 in the papillary thyroid carcinomas and clinical pathology significance. Methods: By the s-p immunohistochemical technique, the expression of p53，ki-67, galectin-3, HBME-1, 34βE12 and CK-19 was detected in 43 cases of papillary thyroid carcinomas, 37 multinodular goiters, 33 follicular adenomas and 17 Hashimoto’s thyroiditis. Results: The expression rate of p53，ki-67, galectin-3, HBME-1, 34βE12 and CK19 in the papillary thyroid carcinomas was 88.37%, 79.07%, 88.37%, 93.02%, 86.05%and 95.35% respectively;　Expression of p53，ki-67, galectin-3, HBME-1, 34βE12 and CK-19 were obviously different in the papillary thyroid carcinomas and benign lesions ( P<0.01). Conclusion: Combined application of immunohistochemical staining of p53，ki-67, galectin-3, HBME-1, 34βE12 and CK-19 is a more useful option to distinguish the papillary thyroid carcinoma from benign lesions.

Key words: papillary thyroid carcinoma, p53, ki-67, galectin-3, HBME-1, 34βE12, CK-19, immunohistochemistry