Abstract: Abstract Puma(p53 up-regulated modulator of apoptosis), a pro-apoptotic member of the Bcl-2 family, has a potential pro-apoptotic activity. Some studies have shown that Puma may be associated with the inhibiting of tumor and induce tumor apoptosis by many ways. In the therapy for tumor, the up-regulated Puma is benefit for chemotherapy, the deletion of Puma is benefit for relieving the side effect of radiotherapy. Recently, the correlative reasearch about the apoptosis of the tumor and the therapy with Puma had became hot, This article will discuss the correlative reasearches for Puma to tumor.

Key words: Puma, tumor, apoptosis