Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (11): 1289-1292.

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Research on Physiological and Pathophysiological Functions of X- box Binding Protein

张霞丽 ZHANG Xia-Li   

  • Received:2010-08-27 Revised:2010-11-27 Online:2011-11-05 Published:2011-11-02
  • Contact: 张霞丽 ZHANG Xia-Li

Abstract: ABSTRACT:X-box binding protein 1 is an important component of unfolded protein response.XBP-1 has two splicing variants that were designated XBP-1S and XBP-1U. The former activity is much higher than the latter. When the cell is on the condition of endoplasmic reticulum stress, XBP-1 is induced by ATF6,and spliced by IRE1,then the functional XBP-1S was transcripted, and activation of unfolded protein response. XBP-1 is an important transcription factor,it has an important regulatory role on cell growth and differentiation.XBP-1 is involved in the genesis,development of many diseases.

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