Abstract: The skin color of human is diversity, there is a direct relation between the number, magnitude, type, distribution of melanosome in melanocytes. The synthesis of melanin and the intercellular movement of melanin are complex and a precise process that determines the distribution and skin pigmentation. There are many factors influence the metabolism of skin melanin, that is tyrosinase, peroxidase, microelement, ultraviolet rays, structural proteins 17, protein receptor 2.

Key words: skin, melanin, melanosome, synthetise, transfer, effect factor