Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (11): 1247-1250.

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Effect of Curcumin Preconditioning on Expression of Myocardial Apoptosis-related Factor in Acute Myocardial Ischemia in rats


  • Received:2010-08-23 Revised:2010-12-23 Online:2011-11-05 Published:2011-11-02
  • Contact: Gao Jian-Zhi

Abstract: 【Abstract】0bjective to investigate the effect of curcumin preconditioning on expression of myocardial apoptosis-related factor in acute myocardial ischemia (AMI) in rats. Methods Thirty SD male rats were randomly divided into acute myocardial ischemia injury rats group, sham-operation group and curcumin-treated AMI group. Detected myocardial apoptosis with the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) technique of all rats.Then infered their apoptosis index.We detected myocardial apoptosis-related factor with RT-PCR technique of all rats and investigated their relations.Results Compared with acute myocardial ischemia injury rats group,their mRNA levels of bcl-2 in curcumin-treated AMI group increased markedly, the myocardial apoptosis index related positively with their mRNA levels of bcl-2; their mRNA levels of caspase-3 in curcumin-treated AMI group decreased signaficantly, the myocardial apoptosis index related negtively with their mRNA levels of caspase-3. Conclusions Curcumin have obviously protective effects on myocardial infarction in the myocar- dial ischemia rats.The mechanism possible related with regulation apoptosis-related factor.

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