Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (11): 1247-1250.
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Abstract: 【Abstract】0bjective to investigate the effect of curcumin preconditioning on expression of myocardial apoptosis-related factor in acute myocardial ischemia (AMI) in rats. Methods Thirty SD male rats were randomly divided into acute myocardial ischemia injury rats group, sham-operation group and curcumin-treated AMI group. Detected myocardial apoptosis with the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) technique of all rats.Then infered their apoptosis index.We detected myocardial apoptosis-related factor with RT-PCR technique of all rats and investigated their relations.Results Compared with acute myocardial ischemia injury rats group,their mRNA levels of bcl-2 in curcumin-treated AMI group increased markedly, the myocardial apoptosis index related positively with their mRNA levels of bcl-2; their mRNA levels of caspase-3 in curcumin-treated AMI group decreased signaficantly, the myocardial apoptosis index related negtively with their mRNA levels of caspase-3. Conclusions Curcumin have obviously protective effects on myocardial infarction in the myocar- dial ischemia rats.The mechanism possible related with regulation apoptosis-related factor.
CLC Number:
R541.4
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2011/V31/I11/1247