Abstract: Objective To study the association of the interleukin-10(IL-10) haplotype polymorphism and the Atopic Dermatitis. Methods 174 Atopic Dermatitis children and 130 healthy children were tested, The frequency of three single nucleotide polymorphisms(SNPs) at positions-1082(A/G), -819(C/T), -592(A/C) and corresponding haplotypes in the promoter region of the IL-10 gene were analysed using Taqman method. The data were assessed for correlations with the eosinophil count and total serum IgE concentration. Results The frequency of IL-10 haplotype ACC in healthy children was higher than that in Atopic Dermatitis children (P﹤0.05) . Meanwhile medians of serum IgE level and total eosinophil count in Atopic Dermatitis children with ATA/ATA genotype were higher than those with ATA/ACC (P﹤0.05) . Conclusion IL-10 promotor polymorphism may be associated with the development of Atopic Dermatitis.

Key words: IL-10, Gene polymorphism, Atopy, Haplotype, Genotype