Abstract: In recent years, researchers have made some breakthroughs on human embryonic stem cells, in particular, on reprogramming differentiated cell (such as human skin fibroblast) into human embryonic stem cell. Induced pluripotent stem cells could be generated from human skin fibroblasts by inducting into four transcription factors known as OCT3/4, SOX2, c-Myc and KLF4. This approach will also enable us to better understand the pathogenesis of diseases from the perspective of genetic component and is also promising in the treatment of related diseases. This article introduces the latest advancement of those researches.

Key words: Human fibroblasts, Stem Cells