Basic & Clinical Medicine ›› 2010, Vol. 30 ›› Issue (2): 113-116.

• 研究论文 •     Next Articles

Increased Expression of Autoantibodies and Soluble IL-6 Receptor in Serum of Patients with Tourette's Syndrome

Yu-hang CHENG, Yi ZHENG, Li-fang WANG, Rui-mei LIU, Yang GAO   

  1. Department of Immunology, IBMS, CAMS & PUMC
  • Received:2009-03-05 Revised:2009-05-22 Online:2010-02-05 Published:2010-02-05
  • Contact: Yang GAO

Abstract: Objective: To explore the mechanism underlying the immunologic injury in TS patients. Methods: The serum levels of anti-brain antibody(ABAb), antinuclear antibody(ANAb), soluble IL-6 receptor (sIL-6R), and soluble gp130 (sgp130) in patients with TS were analyzed by commercialized ELISA kits,and the titer of anti-streptolysin O (ASO) in TS and control was examined with latex enhanced immunoturbidimetry. Results: The levels of sIL-6R and sgp130 were significantly elevated in TS compared with control group (44.1 15.8 vs 30.3 9.0, P<0.01;69.0 24.6 vs 47.3 14.1,P<0.01, respectively) . ASO titer ( 250IU/ml) were found higher in TS than that in control(P 0.01). The positive rates of anti-brain antibody and antinuclear antibody in TS were higher than that in control group as well (66% vs 4% p 0.01; 53% vs 25%, p 0.01). The level of ABAb negatively correlated with sgp130 concentration (r= 0.375, p<0.05). Conclusion: IL-6 signal transduction might be involved in Tourette's syndrome to lead the function upward and start the network mechanism of feedback inhibition, because elevated levels of sIL-6R, sgp130,ANAb and ABAb in serum. Autoimmune-related injuries may participate in the pathogenesis of the disease.

Key words: Tourette’s Syndrome, Autoantibodies, anti-streptolysin O, sIL-6R, sgp130